Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,798 articles
A new study reveals how amyloid beta drains NAD+ from brain endothelial cells, triggering a mitochondrial DNA–innate immune cascade that inflames the aging brain.
New review argues aging stems from disrupted mitochondrial signaling, not ATP loss—and mild complex I inhibition may extend healthspan.
A rigorous mechanistic deep-dive into how transposable element reactivation drives aging at the molecular level — from chromatin topology disruption to therapeutic intervention strategies.
A 270,000-person study finds higher blood tyrosine levels associated with shorter lifespans in men, raising concerns about common focus supplements.
New research reveals how aging senescent cells drive angiogenesis in gut cancers, undermining standard anti-VEGF treatments.
Clearing zombie cells then restoring stem cell activity produced far greater lifespan gains than either approach alone.
Geroscience pioneer Dr Nir Barzilai explains how intervening in aging biology — not individual diseases — may be medicine's biggest leap.
A rare stress-enduring stem cell subpopulation called Muse cells could solve regenerative medicine's biggest failures and slow tissue aging.
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
A prominent biologist argues preclinical aging research needs a reality check to better translate animal findings into human longevity gains.
Combining mesenchymal stem cell transplantation with exercise may overcome key limitations of standalone therapy for sarcopenia.
Go deeper into the mechanisms by which reactivated transposable elements damage DNA, trigger inflammation, and accelerate aging — and what biology is doing to fight back.
