Aged Muscle Stem Cells Lose a Key Fat-Building Metabolic Pathway
Duke researchers find that aging impairs glutamine-driven fat synthesis in muscle stem cells, limiting their repair capacity.
Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
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Duke researchers find that aging impairs glutamine-driven fat synthesis in muscle stem cells, limiting their repair capacity.
CD38 activity rises with age, depleting NAD+ and accelerating tissue decline. New research positions CD38 inhibitors as promising anti-aging therapeutics.
A new vaccination strategy targeting CD38 improved physical function, cognition, metabolism, and NAD+ levels in aging mice — with just a few injections.
A landmark review challenges the 'interference effect' dogma, showing concurrent resistance and endurance training can coexist and even enhance performance.
A comprehensive review reveals what nutrition strategies actually work against sarcopenia — and where critical evidence gaps remain.
Sarcopenia and osteoporosis frequently co-occur in older adults, forming osteosarcopenia — a dual threat to mobility, independence, and survival.
Scientists pinpoint the AKG-IDH1-RPS23 axis as a key regulator of stem cell senescence, opening new doors for anti-aging metabolic therapies.
Senescent tumor endothelial cells secrete INHBB under diabetic conditions, accelerating pancreatic cancer—and blocking its receptor shows therapeutic promise.
Restoring regulatory T cells prevents gut leakiness, dysbiosis, and systemic inflammation—extending healthspan in a mouse aging model.
Discover what free radicals and reactive oxygen species actually are, why they're not purely villains, and how your body uses them as clever signals — with practical steps to keep the balance right for healthy aging.
A major meta-analysis reveals widespread underdiagnosis of Lewy body dementia, the second most common degenerative dementia after Alzheimer's.
A 43-year study of 131,000+ adults found moderate caffeine intake cuts dementia risk by 35% — but more isn't better.