Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,821 articles
A new class of retro-inverso peptides selectively destroys senescent brain cells via the FOXO4-p53 axis, restoring cognition in aged animal models.
Two natural compounds suppress cellular senescence in osteoarthritic cartilage progenitor cells, reducing inflammatory SASP markers via p53 pathway.
New review reveals how energy substrate changes, mitochondrial stress, and nutrient-sensing failures accelerate cardiac aging — and how to fight back.
A major review challenges the evidence behind metformin as a longevity drug, exposing methodological flaws in landmark studies.
A comprehensive review reveals how age-remodeled microenvironments cripple satellite cells, driving muscle loss—and how emerging therapies may reverse it.
Eric Topol argues converging advances in AI and aging biology now make it possible to predict and prevent Alzheimer's decades before symptoms emerge.
Scientists review how hematopoietic stem cells become senescent with age and identify promising therapeutic strategies to restore blood system function.
A new review reveals senescent cells are far more heterogeneous than assumed, with major implications for senolytics and aging therapies.
A new review maps how inducing or eliminating senescent cells could sharpen cancer therapies and improve patient survival.
A landmark review maps how senescent cells fuel gastrointestinal diseases—and why clearing them could transform treatment.
A deep mechanistic exploration of mTOR complex architecture, allosteric regulation, and the cutting-edge therapeutic strategies targeting this pathway for healthspan extension.
New single-cell RNA data reveals how Y chromosome loss reshapes immune cell behavior and unlocks cancer-linked X genes in older men.
