ABCA7 Alzheimer's Gene Disrupts Brain Cell Lipids and Mitochondria
MIT researchers map how ABCA7 loss-of-function variants wreck phosphatidylcholine metabolism and mitochondria in neurons — and find a potential fix.
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MIT researchers map how ABCA7 loss-of-function variants wreck phosphatidylcholine metabolism and mitochondria in neurons — and find a potential fix.
A comprehensive review reveals how immunosenescence and chronic neuroinflammation create a self-reinforcing cycle that accelerates dopaminergic neuron loss in Parkinson's disease.
A Phase 2 trial investigates whether thiethylperazine, a decades-old antiemetic, can flush toxic amyloid beta from the brains of early AD patients.
Contraloid acetate, an oral all-D-peptide designed to disassemble toxic amyloid-beta oligomers, completed its first-in-human safety trial in 40 healthy volunteers.
A 5-year cohort study finds elevated blood palmitoleic acid — a marker of excess energy intake — accelerates brain hypometabolism linked to cognitive decline.
New research across 47,000 adults reveals the cerebellum acts as a brain reserve, helping maintain cognition even as Alzheimer's pathology mounts.
A home-based walking and resistance program improved attention and reduced observable cognitive decline in chemotherapy patients over 6 weeks.
A completed case-control study probes how early and lifetime trauma exposure shapes TMD severity and quality of life.
A Columbia University trial tests whether a hip hop-based dementia education program builds lasting literacy and reduces stigma in children and families.
A 7-year NIH-led study finds over half of Ebola survivors experience lasting cognitive dysfunction, persistent headaches, and depression.
Yale researchers show BCI learning accelerates when neural mappings align with the brain's natural activity geometry, a breakthrough for neurotechnology.
Scientists found acetylcholine surges after unexpected failure, triggering behavioral flexibility — with implications for addiction and OCD.