Heart Disease

675 articles in this topic

Enzyme CTSL Triggers Rogue Notch1 Signaling That Drives Artery-Aging and Plaque
Heart Health

Enzyme CTSL Triggers Rogue Notch1 Signaling That Drives Artery-Aging and Plaque

A novel CTSL–Notch1–CUX1 pathway drives endothelial senescence and atherosclerotic plaque buildup, revealing fresh drug targets.

Research Paper
May 30, 2026 0
Bempedoic Acid Cuts Venous Clot Risk by 42% in Statin-Intolerant Patients
Heart Health

Bempedoic Acid Cuts Venous Clot Risk by 42% in Statin-Intolerant Patients

A post hoc analysis of the CLEAR Outcomes trial finds bempedoic acid significantly reduces DVT and pulmonary embolism risk.

Research Paper
May 29, 2026 0
Prasugrel Beats Ticagrelor and Clopidogrel After Heart Stenting
Heart Health

Prasugrel Beats Ticagrelor and Clopidogrel After Heart Stenting

A 48,904-patient meta-analysis finds prasugrel reduces heart attacks and stent clots better than its rivals after PCI.

Research Paper
May 29, 2026 0
Climate Change and Aging Are Driving a Cardiovascular Crisis Together
Heart Health

Climate Change and Aging Are Driving a Cardiovascular Crisis Together

A new JAMA Cardiology analysis warns that rising temperatures and a growing elderly population are converging to produce an unprecedented cardiac emergency.

Research Paper
May 29, 2026 0
REGENXBIO Hunts LDLR Mutations to Build a Gene Therapy Pipeline for Rare Cholesterol Disorder
Heart Health

REGENXBIO Hunts LDLR Mutations to Build a Gene Therapy Pipeline for Rare Cholesterol Disorder

A completed registry study identified and genotyped HoFH patients with LDLR mutations, laying groundwork for targeted gene therapy.

Clinical Trial
May 28, 2026 0
PCSK9 Inhibitor AK102 Tested Against High-Risk Hypercholesterolemia in Phase 2 Trial
Heart Health

PCSK9 Inhibitor AK102 Tested Against High-Risk Hypercholesterolemia in Phase 2 Trial

Akeso's AK102 faces a placebo-controlled test in high-cardiovascular-risk patients already on statins and ezetimibe.

Clinical Trial
May 27, 2026 0
Pelacarsen Targets Lp(a) in Black and Hispanic Americans With Heart Disease
Heart Health

Pelacarsen Targets Lp(a) in Black and Hispanic Americans With Heart Disease

A completed Phase IIIb trial tests whether pelacarsen can safely lower Lp(a) in historically underrepresented cardiovascular disease populations.

Clinical Trial
May 27, 2026 0
New RNA Drug RBD7022 Enters Phase 1 Testing as Next-Gen LDL Cholesterol Lowerer
Heart Health

New RNA Drug RBD7022 Enters Phase 1 Testing as Next-Gen LDL Cholesterol Lowerer

A phase 1 trial tests RBD7022, a novel subcutaneous RNA-based therapy, for safety and dosing in adults with high LDL cholesterol.

Clinical Trial
May 27, 2026 0
Indoor Cycling Three Times a Week Targets CVD Risk Factors in Women With Obesity
Heart Health

Indoor Cycling Three Times a Week Targets CVD Risk Factors in Women With Obesity

A 3-month interval cycling program assessed cardiovascular and metabolic improvements in obese vs. normal-weight women.

Clinical Trial
May 27, 2026 0
Anticoagulation Clinics Show How to Manage Heart Medications Smarter
Heart Health

Anticoagulation Clinics Show How to Manage Heart Medications Smarter

Experts propose that structured anticoagulation services offer a blueprint for broader cardiovascular medication stewardship programs.

Research Paper
May 27, 2026 0
2025 AHA/ACC Hypertension Guidelines Get Official Correction Update
Heart Health

2025 AHA/ACC Hypertension Guidelines Get Official Correction Update

A formal correction is issued to the landmark 2025 multi-society hypertension guidelines, ensuring clinical accuracy for practitioners.

Research Paper
May 27, 2026 0
Breast Cancer Treatment Uncovers Hidden BMPR2 Risk for Pulmonary Hypertension
Heart Health

Breast Cancer Treatment Uncovers Hidden BMPR2 Risk for Pulmonary Hypertension

A correction to a landmark study linking breast cancer to latent BMPR2-driven pulmonary hypertension susceptibility in Circulation.

Research Paper
May 27, 2026 0
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