746 articles in this topic
Dive into the molecular machinery behind lifelong brain health — from BDNF-TrkB signaling cascades and adult hippocampal neurogenesis to glymphatic amyloid clearance and cutting-edge interventions including senolytics, GLP-1 agonists, and transcranial stimulation.
Explore what actually happens inside your brain as you get older — from shrinking neuron networks to shifting brain chemicals — and discover why some people stay mentally sharp well into their 80s and beyond.
Blocking the protein PTP1B boosted memory and cleared brain plaque in mice, with potential links to diabetes and obesity treatment.
Norwegian cohort study finds paternal valproate users have significantly higher epilepsy polygenic risk scores, suggesting genetic confounding may explain reported child neurodevelopmental risks.
A year-long sham-controlled trial finds active VNS meaningfully improves daily function and quality of life in patients who failed 4+ antidepressants.
A 2018 paper on antileukotriene therapy and tau phosphorylation in Alzheimer's mice has been retracted due to image fraud.
MethylCog, a 29-CpG blood test, indexes general cognitive ability and improves mild cognitive impairment detection beyond age and sex alone.
Neuropixels recordings reveal how laminar microcircuits generate interictal epileptiform discharges — and how to predict them 1 second in advance.
NfL biomarker levels in NORSE patients were 10-fold higher in CSF and 4-fold higher in serum than other seizure disorders, signaling massive neuroaxonal injury.
A 9-day intranasal insulin regimen restored working memory, recognition memory, and reduced neuroinflammation in mice engineered to mimic hippocampal aging.
Leading neurologists argue that amyloid aggregation dynamics may be distorting how we read clinical trial results for Alzheimer's immunotherapies.
A multi-omics subspace-merging algorithm identifies biologically distinct AD subtypes, pointing toward personalized treatment strategies.
