p53-DDIT4-NF-ฮบB Pathway Drives Depression โ Curcumin Blocks It
New research maps a stress-signaling cascade linking p53 activation to brain inflammation and depression, with curcumin interrupting it.
960 articles in this topic
New research maps a stress-signaling cascade linking p53 activation to brain inflammation and depression, with curcumin interrupting it.
A comprehensive review examines how marine-derived bioactives like omega-3s, astaxanthin, and polysaccharides may combat chronic neuroinflammation underlying major neurodegenerative diseases.
New research reveals how glucose availability directs brain cell proliferation via a metabolic-epigenetic axis, with implications for MS and brain repair.
Penn State researchers found abdominal contractions create pressure waves that gently rock the brain, boosting cerebrospinal fluid flow and waste clearance.
Raising Sox9 levels in aging astrocytes reduced amyloid plaque buildup and protected memory in mouse models with existing Alzheimer's symptoms.
Multi-night home sleep tests rival lab polysomnography for uncomplicated OSA, cutting costs and improving patient experience.
A meta-analysis of 684,493 patients finds just 49% persist with anti-dementia drugs at 12 months, with major variation by drug type and study methodology.
A multi-cohort study finds that every 5 km closer to a lead-releasing facility is tied to measurably lower episodic memory scores.
Intracranial recordings reveal a low-dimensional subspace in human prefrontal cortex that selectively transmits context-relevant signals to motor cortex.
Master the molecular machinery of sleep-dependent brain clearance, dissect melatonin's chronobiological role, and apply evidence-based protocols โ from CBT-I to pharmacological aids โ to engineer restorative sleep for longevity.
Explore the mechanistic changes in sleep architecture as we age โ from shrinking slow-wave sleep to disrupted circadian clocks โ and how these shifts cascade into hormonal, inflammatory, and metabolic dysfunction.
Dive into the molecular machinery behind lifelong brain health โ from BDNF-TrkB signaling cascades and adult hippocampal neurogenesis to glymphatic amyloid clearance and cutting-edge interventions including senolytics, GLP-1 agonists, and transcranial stimulation.