Cancer Research
Blocking Autophagy Supercharges Lung Cancer Immunotherapy Response
Adding an autophagy inhibitor to anlotinib plus PD-1 blockade dramatically reshapes the tumor microenvironment in NSCLC models.
Research Paper
May 22, 2026 0
Cancer
680 articles in this topic
Cancer Research
Ferroptosis Boosts Anti-Tumor Immunity by Degrading the Immune Suppressor SHP2
RSL3-induced ferroptosis degrades SHP2 via chaperone-mediated autophagy, amplifying IFN-γ/STAT1 signaling and enhancing anti-PD-1 immunotherapy efficacy.
Research Paper
May 22, 2026 0
Cancer Research
Tumor Cholesterol Blocks PD-L1 Destruction to Escape Immune Attack
Cancer cells exploit cholesterol biosynthesis to keep PD-L1 high, silencing T cells — and blocking this pathway restores anti-tumor immunity.
Research Paper
May 22, 2026 0
Cancer Research
Hidden Protein Shields Liver Cancer Cells From a Key Cell Death Pathway
Scientists uncover how SCRN1 blocks ferroptosis in liver cancer, revealing new targets for treating drug-resistant hepatocellular carcinoma.
Research Paper
May 22, 2026 0
Cancer Research
Engineered Tumor Switches Destroy Glioblastoma While Building Lasting Immunity
Synthetic super-enhancers hijack glioblastoma's own regulatory circuits to trigger precise, tumor-only cell death and durable immune memory.
Research Paper
May 22, 2026 0
Cancer Research
HER2 Cancer Therapy Gets a Rethink With Immune System at the Center
New review reveals how HER2 reshapes the tumor immune environment — and why beating it requires more than blocking the oncogene.
Research Paper
May 22, 2026 0
Cancer Research
Cancer Cells Hide from Antibody-Drug Conjugates by Blocking Internalization
Researchers uncover how cancer cells evade ADC therapy by suppressing drug uptake — and identify a drug target to reverse resistance.
Research Paper
May 22, 2026 0
Cancer Research
FDA Approves Oral AML Therapy for Elderly Patients Unfit for Intensive Chemo
Inqovi gains approval for newly diagnosed AML in patients 75+ or with comorbidities, offering a gentler oral treatment route.
Drug Approval
May 22, 2026 0
Cancer Research
Tumor Stiffness Drives Ferroptosis Sensitivity Through Iron Recycling Autophagy
Mechanical tension in the tumor microenvironment controls iron metabolism and cell death susceptibility via a novel NCOA4-FTH1 autophagy axis.
Research Paper
May 21, 2026 0
Cancer Research
New Mechanism Found That Could Reverse Drug Resistance in Colorectal Cancer
Scientists identify how the HMBOX1-HACE1-ATG5 axis suppresses autophagy to restore 5-FU chemosensitivity in colorectal cancer.
Research Paper
May 21, 2026 0
Cancer Research
Dormant Breast Cancer Cells Slashed 80–87% by Repurposed Drugs in Phase 2 Trial
A randomized trial shows hydroxychloroquine and everolimus can dramatically reduce dormant tumor cells in breast cancer survivors, potentially preventing relapse.
Research Paper
May 21, 2026 0
Cancer Research
Metabolic Enzyme DLAT Hijacks Leucine Breakdown to Fuel Liver Cancer Growth
A pyruvate metabolism enzyme suppresses leucine catabolism to keep mTOR active in liver cancer — and blocking it shrinks tumors in vivo.
Research Paper
May 21, 2026 0