Advanced Therapies

3258 articles in this topic

iTTP Survival Jumps From Near Zero to 93% With Modern Treatment Trio
Longevity & Aging

iTTP Survival Jumps From Near Zero to 93% With Modern Treatment Trio

A 2025 JAMA review breaks down how plasma exchange, rituximab, and caplacizumab transformed survival in this rare blood-clotting emergency.

Research Paper
May 18, 2026 0
How Premature Immune Aging Drives Rheumatoid Arthritis Onset and Severity
Longevity & Aging

How Premature Immune Aging Drives Rheumatoid Arthritis Onset and Severity

RA patients show accelerated immune aging in T cells, B cells, and myeloid cells—predating joint inflammation and directly fueling autoimmunity.

Research Paper
May 18, 2026 0
Autophagy Both Drives and Suppresses Ferroptosis Depending on Cell Context
Longevity & Aging

Autophagy Both Drives and Suppresses Ferroptosis Depending on Cell Context

New research reveals autophagy's dual role in ferroptosis—sometimes triggering cell death, sometimes preventing it—depending on iron, lipid, and radical levels.

Research Paper
May 18, 2026 0
Low-Intensity Ultrasound Clears Kidney Stones in 70% of Patients Without Anesthesia
Longevity & Aging

Low-Intensity Ultrasound Clears Kidney Stones in 70% of Patients Without Anesthesia

The Break Wave device shatters kidney stones into passable fragments in 7 of 10 patients, no anesthesia needed, in a clinic setting.

Press Release
May 18, 2026 0
Mammogram Timing Confusion Explained — What Women Need to Know Now
Longevity & Aging

Mammogram Timing Confusion Explained — What Women Need to Know Now

Health groups disagree on when to start mammograms. Here's how to navigate conflicting screening guidelines and make an informed decision.

Press Release
May 18, 2026 0
Smart Nanoparticles Reverse Alzheimer's Symptoms in Mice by Rebooting Brain Cleanup
Longevity & Aging

Smart Nanoparticles Reverse Alzheimer's Symptoms in Mice by Rebooting Brain Cleanup

Engineered nanoparticles cleared 50-60% of toxic amyloid plaques within 1 hour and restored the blood-brain barrier in Alzheimer's mice.

Press Release
May 18, 2026 0
Why Older Adults Get Less Protection From Flu and Shingles Vaccines
Longevity & Aging

Why Older Adults Get Less Protection From Flu and Shingles Vaccines

A completed Phase 2 trial investigates the immune mechanisms behind age-related vaccine failure in older adults.

Clinical Trial
May 18, 2026 0
Peter Attia Builds a Practical Framework for Getting Real Value From Genetic Tests
Longevity & Aging

Peter Attia Builds a Practical Framework for Getting Real Value From Genetic Tests

Most genetic tests are probabilistic, not deterministic. Attia explains when DNA data truly changes decisions and when it just adds noise.

Podcast
May 18, 2026 0
CD38 Links Heart and Brain Disease Through Shared Molecular Pathways
Longevity & Aging

CD38 Links Heart and Brain Disease Through Shared Molecular Pathways

A comprehensive review reveals how the enzyme CD38 drives cardiovascular and neurological disease through calcium, NAD+, and inflammation signaling.

Research Paper
May 17, 2026 0
NAD Deficiency Triggers a Fake Viral Alarm Via Mitochondrial DNA Leakage
Longevity & Aging

NAD Deficiency Triggers a Fake Viral Alarm Via Mitochondrial DNA Leakage

Chronic NAD depletion causes mitochondrial DNA to escape into the cytoplasm, activating an interferon response that mimics a viral infection.

Research Paper
May 17, 2026 0
CD38-High Monocytes Flag Sepsis Early and Open New Treatment Door
Longevity & Aging

CD38-High Monocytes Flag Sepsis Early and Open New Treatment Door

A novel immune cell subset, CD38-high monocytes, spikes within 24 hours of sepsis onset and may serve as both a diagnostic marker and drug target.

Research Paper
May 17, 2026 0
Age-Related Loss of Nerve-Linked Macrophages Drives Fat Tissue Inflammation
Longevity & Aging

Age-Related Loss of Nerve-Linked Macrophages Drives Fat Tissue Inflammation

A specialized immune cell population near adipose nerves declines with age, fueling inflammaging and disrupting fat metabolism.

Research Paper
May 17, 2026 0
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