Cancer Cells Hijack a Protein Switch to Survive Oxidative Death
A newly discovered succinylation-desuccinylation switch on GCLC lets cancer cells ramp up antioxidant GSH production and evade ferroptosis.
4,573 articles in this topic
A newly discovered succinylation-desuccinylation switch on GCLC lets cancer cells ramp up antioxidant GSH production and evade ferroptosis.
New research reveals how mitochondrial NAD+ controls mitophagy to prevent cytosolic mtDNA from triggering chronic inflammation via the CGAS-STING pathway.
Master the cutting-edge molecular pharmacology of Wnt pathway modulation — from small-molecule β-catenin activators to senescence-driven inhibitor networks — and understand how researchers are translating these mechanisms into regenerative therapies.
New ACS guidance allows blood-based colorectal cancer screening but critics warn the framework is too vague to prevent misuse.
NeuroXT and BIDMC expand their AI-imaging collaboration to predict which Alzheimer's patients will respond to which therapies.
UniXell's iPSC-derived dopamine cell therapy UX-DA003 clears regulators in both the U.S. and China, enabling global Parkinson's trials.
A 260-infant RCT tests whether adding bleomycin injections to low-dose propranolol accelerates hemangioma regression and improves skin outcomes.
Senescent endothelial cells that accumulate after bone injury sabotage stem cell repair — and quercetin delivered locally can reverse this.
A new mitochondrial epigenetic editor silences aging-linked genes without altering DNA sequence, opening doors to programmable longevity interventions.
Chlorogenic acid boosts ATP by up to 80%, clears senescent cells, and rebuilds collagen — potentially redefining topical anti-aging treatment.
Epigenetic clock pioneer Steve Horvath breaks down which everyday interventions measurably shift biological age — and which don't.
New research reveals that both abnormally short and ultra-long telomeres cause distinct inherited diseases, reshaping how we understand aging and cancer risk.