Advanced Therapies

4,573 articles in this topic

Gut Enzyme ST8Sia6 Acts as a Molecular Brake on Intestinal Inflammation
Longevity & Aging

Gut Enzyme ST8Sia6 Acts as a Molecular Brake on Intestinal Inflammation

Mice lacking the sialyltransferase ST8Sia6 develop spontaneous small bowel immune activation and heightened colitis susceptibility, revealing a new glycosylation-based immune checkpoint.

Research Paper
Jun 27, 2026 0
Scientists Discover How C. difficile Toxin Hijacks Macrophages to Fuel Gut Inflammation
Longevity & Aging

Scientists Discover How C. difficile Toxin Hijacks Macrophages to Fuel Gut Inflammation

Researchers identify CD44 as the macrophage receptor for TcdB toxin, revealing a succinylation-driven inflammatory pathway with new therapeutic implications.

Research Paper
Jun 27, 2026 0
NAT10 Enzyme Drives Sepsis Heart Damage — Blocking It May Save Lives
Longevity & Aging

NAT10 Enzyme Drives Sepsis Heart Damage — Blocking It May Save Lives

A newly identified RNA modification pathway in macrophages fuels deadly cardiac dysfunction during sepsis, and blocking it with a drug reverses the damage.

Research Paper
Jun 27, 2026 0
RNA Sugar Coating Hides Self-RNA from Immune Attacks and Enables Silent Cell Cleanup
Longevity & Aging

RNA Sugar Coating Hides Self-RNA from Immune Attacks and Enables Silent Cell Cleanup

Scientists reveal that N-glycan 'shields' on small RNAs prevent immune flare-ups—unlocking a new paradigm for autoimmunity and cell death biology.

Research Paper
Jun 27, 2026 0
Brain-Computer Interfaces Show Promise for Restoring Movement After Stroke
Longevity & Aging

Brain-Computer Interfaces Show Promise for Restoring Movement After Stroke

EEG-based neurofeedback and BCI technologies are emerging as evidence-based tools to restore upper limb function in stroke survivors.

Research Paper
Jun 27, 2026 0
Neurofeedback Trains the Depressed Brain Without Drugs
Longevity & Aging

Neurofeedback Trains the Depressed Brain Without Drugs

Brain-computer interfaces using EEG and fMRI let depression patients self-regulate neural activity, showing real promise as a non-drug treatment.

Research Paper
Jun 27, 2026 0
Brain Stimulation Therapies Show Promise for Adult ADHD but Need Larger Trials
Longevity & Aging

Brain Stimulation Therapies Show Promise for Adult ADHD but Need Larger Trials

A meta-analysis comparing neurofeedback, tDCS, and TMS for adult ADHD finds encouraging signals but no technique yet reaches statistical significance.

Research Paper
Jun 27, 2026 0
Brain-Computer Interfaces Revolutionize Stroke Rehab Beyond Motor Recovery
Longevity & Aging

Brain-Computer Interfaces Revolutionize Stroke Rehab Beyond Motor Recovery

BCI technology shows transformative potential for restoring motor function, cognition, and emotional health in stroke survivors.

Research Paper
Jun 27, 2026 0
Psychedelics Hit Dozens of Brain Receptors Beyond Serotonin
Longevity & Aging

Psychedelics Hit Dozens of Brain Receptors Beyond Serotonin

A landmark screen of 41 psychedelics across 318 receptors reveals surprisingly broad pharmacology with major therapeutic implications.

Research Paper
Jun 27, 2026 0
Psilocybin Rewires Brain Networks Through Activity-Dependent Synaptic Plasticity
Longevity & Aging

Psilocybin Rewires Brain Networks Through Activity-Dependent Synaptic Plasticity

A single psilocybin dose reshapes cortical connectivity in mice by strengthening perceptual pathways and weakening recurrent loops—driven by acute neural firing.

Research Paper
Jun 27, 2026 0
How Trauma Rewires the Brain: Neuroplasticity's Role in PTSD Development and Recovery
Longevity & Aging

How Trauma Rewires the Brain: Neuroplasticity's Role in PTSD Development and Recovery

A 2025 review reveals how synaptic and myelin plasticity changes in the amygdala-hippocampus-prefrontal circuit drive PTSD — and how to reverse them.

Research Paper
Jun 27, 2026 0
Psilocybin Rewires the Brain Through More Than One Receptor
Longevity & Aging

Psilocybin Rewires the Brain Through More Than One Receptor

New research reveals psilocybin's neuroplasticity effects involve multiple receptor types beyond 5-HT2A, including TrkB, reshaping drug development.

Research Paper
Jun 27, 2026 0
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