4,549 articles in this topic
A new review reveals how natural compounds could modulate EZH2 — a critical epigenetic enzyme — to slow aging without the risks of strong drug inhibition.
A new review argues that systemic blood recalibration and partial cellular reprogramming target different axes of aging and should be combined.
A systematic review of 27 human trials finds calorie restriction best modulates senescence markers, but direct evidence remains elusive.
Excess dietary phosphate raises FGF23, which crosses into the brain and triggers sympathetic overactivation and high blood pressure via FGFR4.
A comprehensive review of hyperphosphatemia covers phosphate physiology, hormonal regulation, and clinical consequences for aging and kidney health.
New review reveals how declining Klotho levels drive insulin resistance and type 2 diabetes, positioning this anti-aging protein as a potential biomarker.
A UK Biobank study of 38,000+ adults finds that high fitness delays the onset of multiple chronic diseases by over a year.
A meta-analysis of 38 studies reveals older heart failure patients have dramatically lower peak oxygen uptake than controls, declining further with each decade.
Cardiorespiratory fitness independently predicts morbidity and mortality. Danish review explains why VO₂max may be your most important health metric.
A landmark review maps the dose-response curve between cardiorespiratory fitness and mortality, revealing J-shaped risks at exercise extremes.
Celastrol outperforms leading senolytics by targeting the Hsc70-Bim protein complex, clearing zombie cells and reducing organ fibrosis in mice and flies.
A pilot study finds structured moderate exercise doesn't trigger aortic events in dissection survivors, challenging decades of medical caution.
