Hidden Metabolic Loop Lets Liver Cancer Dodge Immunotherapy
A newly discovered enzyme-driven feedback cycle helps liver tumors suppress immunity and resist checkpoint blockade — and blocking it may help.
675 articles in this topic
A newly discovered enzyme-driven feedback cycle helps liver tumors suppress immunity and resist checkpoint blockade — and blocking it may help.
A new Oxford tool using 5.6 million patient records shows serious statin muscle side effects are rare, yet 60% of eligible patients skip the drug.
A neoantigen peptide vaccine targeting IDH1-R132H mutation doubled median survival in grade IV astrocytoma patients vs. historical benchmarks.
A comprehensive review maps the distinct molecular mechanisms and emerging therapies across all four thyroid cancer subtypes.
Phase 3 trial pits next-gen GnRH antagonist degarelix against standard goserelin in prostate cancer hormone suppression.
A new review reveals how senescent healthy cells within tumors quietly drive cancer progression and therapy resistance.
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A completed phase 2 trial tested nab-paclitaxel combined with the checkpoint inhibitor pembrolizumab in patients with advanced urothelial cancer who cannot tolerate cisplatin.
A phase II trial tests whether 1Gy intestinal radiation can re-sensitize solid tumors that have stopped responding to immunotherapy.
USC researchers unlocked a scalable supply of engineered immune-cell precursors that fight tumors and may revolutionize cancer immunotherapy.
Experimental PCAI compounds blocked over 90% of pancreatic cancer cell migration and triggered self-destruction by hyperactivating tumor growth pathways.
A Phase 2 trial examines whether adding the anti-angiogenic drug bevacizumab to standard chemo improves outcomes in pediatric sarcoma.