Your VO2 Max in Your 70s Could Cut Alzheimer's Risk in Half
Older adults with higher cardiorespiratory fitness had ~48% lower Alzheimer's risk over 8.7 years, with a clear VO2 threshold identified.
1,221 articles in this topic
Older adults with higher cardiorespiratory fitness had ~48% lower Alzheimer's risk over 8.7 years, with a clear VO2 threshold identified.
Two small clinical trials show BCG vaccination alters immune activity in cerebrospinal fluid and changes amyloid-β levels in older adults.
A Canadian RCT tests whether virtual aerobic, resistance, and cognitive training can feasibly combat mild cognitive impairment at home.
High-intensity home cycling improved ataxia symptoms, fatigue, and VO2max significantly more than dose-matched balance training over one year.
A Nature study reveals peripheral immune cells migrate to the brain during sleep to clear toxic lipids — and disrupting this causes memory loss and shortened lifespan.
A pilot RCT tests whether the SysLife© app can reduce subjective stress and improve functioning in work and personal life.
A large-scale genomic study identifies 39 shared genetic loci between schizophrenia and Alzheimer's disease, converging on chromosome 16p11.2.
A nested study within the PREDIMED trial finds elevated resistin — an adipose-derived hormone — associated with 56% higher odds of incident Alzheimer's disease.
A 30-study review finds exercise and mindfulness alter resting brain connectivity, but the largest rigorous trial shows minimal effects.
First large proteomic study in Nigerian and Tanzanian adults links plasma proteins to amyloid pathology, expanding Alzheimer's biomarker research beyond Western cohorts.
New evidence suggests sleep regularity — not just total hours — may be a stronger predictor of cardiovascular and all-cause mortality risk.
New research proposes delirium as the key mechanistic link explaining why severe infections dramatically raise dementia risk.