3247 articles in this topic
Scientists created stem cell models of Wiedemann-Rautenstrauch syndrome, uncovering how POLR3A mutations disrupt nucleoli and trap telomerase RNA.
A comprehensive 2025 review charts the signaling pathways, drug targets, and emerging strategies scientists are using to slow human aging.
A systematic review reveals how bioactive food compounds modulate telomerase activity to potentially prevent hepatocellular carcinoma.
A 2025 review maps the most promising drug targets and novel strategies—from gene therapy to gut microbiome interventions—for treating MASH.
A new open-access lipidomics database reveals how cholesterol dysregulation in astrocytes may drive Alzheimer's neuroinflammation.
A 2025 JCI review maps nonopioid analgesic targets across inflammatory, neuropathic, and nociplastic pain, spotlighting ion channels, GPCRs, and emerging gene therapies.
A new iPSC method simultaneously activates two transcription factors to grow perfusable vascular organoids in 5 days, outpacing prior 3-week protocols.
Small molecule AA-20 clears protein aggregates and lipid droplets, extending C. elegans lifespan through a novel mTOR-independent autophagy pathway.
A massive 45,000-patient study reveals that higher cardiorespiratory fitness dramatically lowers death risk in chronic kidney disease.
A comprehensive review reveals how physical activity prevents and treats both type 1 and type 2 diabetes, while unpacking the barriers that keep patients sedentary.
A 24,853-person Norwegian cohort study finds that maintaining cardiorespiratory fitness above the bottom 20% largely offsets alcohol's mortality risk.
Scientists reveal how thymine DNA glycosylase removes the adenine oxidation lesion oxoA, a DNA damage implicated in cancer and aging.
