3258 articles in this topic
A comprehensive review of pathophysiology, genetics, and emerging therapies for mitochondrial myopathies, spotlighting elamipretide and gene therapy.
A phase 2b trial finds allogeneic MSC infusions improved 6-minute walk distance by 63 meters vs placebo at 9 months in frail older adults.
A unified mathematical model shows stem cell division rates — not methylation errors — explain why longer-lived species age more slowly.
From refillable eye implants to suprachoroidal injections, next-gen delivery platforms are slashing treatment burden for AMD and diabetic eye disease.
A new PNAS study reveals how mitochondrial free radicals trigger the ATM-CHK2 DNA damage pathway to coordinate three key steps of mitophagy.
Scientists identify a ZBP1-RIPK1 molecular axis that detects oxidized mitochondrial DNA and ignites brain inflammation in Alzheimer's disease.
A muscle-secreted protein boosted by exercise declines with age — restoring it in old mice reverses muscle weakness and bone loss.
Uremic toxins impair mitochondrial cleanup in osteocytes, revealing new drug targets to protect bones in chronic kidney disease.
BioMapAI integrates five omics layers from 249 participants to classify ME/CFS and uncover gut-immune-metabolome drivers of heterogeneous symptoms.
The CIMA project profiles 10M+ immune cells from 428 adults, uncovering how sex, age, and genetics shape immune function at molecular resolution.
New mouse study finds mitochondrial energy coupling stays intact with age, but subtle structural losses and sarcopenia still limit performance.
A 2025 meta-analysis of 15 RCTs finds IF significantly reduces body weight, BMI, and LDL cholesterol while lowering diastolic blood pressure.
