Advanced Therapies

Houdini Bio's Gene Therapy Hack Keeps Therapeutic DNA Switched On Longer

A London startup uses machine learning to stop cells silencing gene therapies, potentially cutting doses and extending treatment durability.

Press Release

Regenerative Medicine

Engineered Blood Vessels Unlock Functional Maturity in Lab-Grown Insulin-Producing Islets

Adding a vascular network to stem cell-derived islet organoids dramatically improves beta-cell calcium signaling, insulin secretion, and diabetes reversal in mice.

Regenerative Medicine

Liquid-Phase Droplets Inside Cells May Unlock Drugs for 'Undruggable' Proteins

Biomolecular condensates formed by liquid-liquid phase separation offer a new platform for clearing disease-causing proteins conventional drugs can't target.

Review

AI Identifies Four Natural Compounds That May Slow Aging on Multiple Fronts

Graph neural networks pinpoint synergistic natural compound pairs targeting four core aging pathways simultaneously.

Regenerative Medicine

Rapamycin and Nicotinamide Reverse Aging in Stem Cells From Elderly Donors

A short-term drug combo rejuvenates aged mesenchymal stem cells, boosting proliferation and reducing inflammatory markers in vitro.

Dog Aging Project Builds Landmark Multi-Omic Cohort to Decode Aging Biology

The Dog Aging Project enrolled 976 companion dogs to collect longitudinal multi-omic data—epigenome, microbiome, metabolome—as a translational aging model.

Dog Disease Networks Reveal Age-Linked Comorbidity Patterns Relevant to Human Health

Scientists mapped 160 canine diseases across 26,614 dogs, uncovering how conditions cluster together—and how these patterns intensify with age.

Dog Gut Microbiomes Reveal Aging Clocks and Human Health Parallels

A 900-dog study maps how gut microbiome composition shifts with age, diet, and behavior — with striking parallels to human aging patterns.

Dogs and Humans Share the Same Blood Metabolite Signatures of Death Risk

A landmark Dog Aging Project study finds plasma metabolites predicting all-cause mortality in dogs mirror those in nine human cohort studies.

How Exercise Keeps Your Brain Young via Muscle-Secreted Signals

A 2025 review reveals how skeletal muscle communicates with the brain through myokines, metabolites, and vesicles to slow cognitive ageing.

How Radiotherapy Damages Healthy Tissue and What Science Is Doing About It

A landmark NEJM review reveals the biological mechanisms behind radiation-induced normal tissue injury and emerging strategies to minimize harm.