3258 articles in this topic
A landmark multi-omic study of 300+ adults reveals non-linear T cell reprogramming and TH2 bias in midlife that blunts vaccine responses.
A new bioenergetic framework reframes aging and disease as consequences of excess cellular energy resistance in biological circuits.
A randomized trial found moderate-to-vigorous exercise reduced brain-predicted age gap by ~1 year in adults aged 26–58.
A landmark study integrating genome, methylome, transcriptome, and proteome data from 1,000+ participants reveals five master exercise genes in muscle.
A landmark study finds muscle mitochondrial respiration and cardiorespiratory fitness—not just socioeconomic factors—explain slower walking speeds in older Black adults.
A 16:8 TRF regimen extended lifespan and improved gut integrity in fruit flies—without sacrificing reproductive fitness or physical activity.
A pilot trial shows a recipe-based FMD reduces body fat and IGF-1 while preserving muscle mass in breast cancer patients undergoing chemotherapy.
A 800-mouse study across 10 genetically diverse strains finds IF extended lifespan in males but not females, with outcomes heavily shaped by genetic background.
Mouse study shows FMD cycles dramatically reduce acute kidney injury and CKD progression by suppressing CCL2-driven monocyte infiltration.
Delphinidin, a natural anthocyanin, prevented microglial senescence via AMPK/SIRT1 signaling, reducing amyloid plaques and restoring cognition in AD mice.
A randomized trial shows older adults with insomnia experience dramatically greater depressive responses when exposed to inflammatory challenge.
A decade of evidence shows poly-L-lactic acid triggers collagen-rebuilding cascades, reshaping aesthetic medicine into regenerative therapy.
