4,593 articles in this topic
A unique N-glycan pattern on anti-MAG IgM antibodies fuels complement activation and macrophage inflammation, revealing new therapeutic targets.
Protein sugar modifications called N-glycans change predictably with age and may serve as reversible biomarkers of biological aging across organ systems.
In children with lupus nephritis, aberrantly glycosylated IgG reprograms podocyte metabolism, opening new biomarker and therapeutic targets.
A 2025 review reveals how altered IgG glycosylation patterns fuel neurological autoimmune diseases and points to glycan-based diagnostics and therapies.
A 2025 review reveals how damaged mitochondrial fragments drive brain inflammation while functional mitochondria transfer rescues injured neurons.
Scientists engineered macrophages with healthy donor mitochondria, dramatically improving their ability to repair heart tissue after myocardial infarction.
A new protein-binder system precisely targets donor mitochondria to diseased cell types, reversing neurodegeneration in human and mouse models.
Scientists isolate mitochondria-packed vesicles from healthy muscle tissue that transfer mitochondrial DNA to damaged cells, restoring energy metabolism.
A meta-analysis of 8 RCTs finds TA-65 modestly elongates telomeres, especially in adults over 60, but doesn't translate to frailty or inflammation benefits.
ALT cancers insert centromeric DNA at telomeres, forming protective chromatin that sustains tumor survival without telomerase.
Stem cell-derived exosomes show strong preclinical promise for repairing cartilage, bone, and synovial tissue with fewer risks than cell-based therapies.
After 120 years of failed attempts, genetic engineering is finally making xenotransplantation viable. Here's where the science stands.
