7263 articles
A new open-access lipidomics database reveals how cholesterol dysregulation in astrocytes may drive Alzheimer's neuroinflammation.
A 2025 JCI review maps nonopioid analgesic targets across inflammatory, neuropathic, and nociplastic pain, spotlighting ion channels, GPCRs, and emerging gene therapies.
A new iPSC method simultaneously activates two transcription factors to grow perfusable vascular organoids in 5 days, outpacing prior 3-week protocols.
Small molecule AA-20 clears protein aggregates and lipid droplets, extending C. elegans lifespan through a novel mTOR-independent autophagy pathway.
A massive 45,000-patient study reveals that higher cardiorespiratory fitness dramatically lowers death risk in chronic kidney disease.
A comprehensive review reveals how physical activity prevents and treats both type 1 and type 2 diabetes, while unpacking the barriers that keep patients sedentary.
A 24,853-person Norwegian cohort study finds that maintaining cardiorespiratory fitness above the bottom 20% largely offsets alcohol's mortality risk.
Scientists reveal how thymine DNA glycosylase removes the adenine oxidation lesion oxoA, a DNA damage implicated in cancer and aging.
A new intact mass spec method reveals all people carry asymmetrically glycosylated antibodies, reshaping how IgG glycans drive infectious disease.
A new lipid-based aging clock built from prefrontal cortex lipidomics detects accelerated aging in autism, schizophrenia, and Down syndrome.
Researchers define 'food noise' as persistent, unwanted food thoughts causing distress, and introduce the first validated questionnaire to measure it.
A 66-study systematic review links breakfast omission to obesity, gut disruption, cancer risk, cognitive decline, and psychiatric disorders.
