2910 articles in this topic
A new PNAS study reveals how mitochondrial free radicals trigger the ATM-CHK2 DNA damage pathway to coordinate three key steps of mitophagy.
Scientists identify a ZBP1-RIPK1 molecular axis that detects oxidized mitochondrial DNA and ignites brain inflammation in Alzheimer's disease.
A muscle-secreted protein boosted by exercise declines with age — restoring it in old mice reverses muscle weakness and bone loss.
Uremic toxins impair mitochondrial cleanup in osteocytes, revealing new drug targets to protect bones in chronic kidney disease.
BioMapAI integrates five omics layers from 249 participants to classify ME/CFS and uncover gut-immune-metabolome drivers of heterogeneous symptoms.
The CIMA project profiles 10M+ immune cells from 428 adults, uncovering how sex, age, and genetics shape immune function at molecular resolution.
New mouse study finds mitochondrial energy coupling stays intact with age, but subtle structural losses and sarcopenia still limit performance.
A 2025 meta-analysis of 15 RCTs finds IF significantly reduces body weight, BMI, and LDL cholesterol while lowering diastolic blood pressure.
New evidence-based recommendations target antenatal and preoperative care to boost recovery outcomes for cesarean patients and their newborns.
The landmark DPP trial shows lifestyle intervention delays diabetes onset by 3.5 years, metformin by 2.5 years, over two decades of follow-up.
A Cochrane review of 22 RCTs finds intermittent fasting produces little to no additional weight loss compared to regular dietary advice or no intervention.
Dihydromyricetin, found in vine tea, acts as a dual senotherapeutic—suppressing SASP in fibroblasts and eliminating senescent microglia in Alzheimer's mice.
